Signaling in A Random Boolean Network
(joint work with Rick Durrett)
A random Boolean network (RBN) is a system of n binary-state nodes with
k input connections to each node and a binary-valued response function
describing the dependence of the state of a node on its input nodes.
One can think of the state of a node representing active or inactive
status, and the response function of a node as its regulatory
mechanism. Randomness appears in this network in two ways: the
configuration of inputs for each node is chosen randomly, and the
regulating response function for each node is chosen randomly from the
set of all binary-valued functions with a $p$ bias towards active
states.
Random Boolean networks were originally developed by Kauffman (1969) as
a model for genetic regulatory networks. We will show that one can use
the threshold contact process (with threshold 1) to approximate the
dynamics of an RBN on a fixed underlying random graph. In the limit as
the number of nodes in the network goes to infinity, there is a phase
transition in its behavior. We identify the phase transition curve in
terms of the parameters of the model, and show that the system either
settles into a steady state fairly quickly, or exhibits stochastic
behaviour for an exponentially long period of time.